The painting shows the vision of the Blessed Clare of Rimini, who led a pious life of self-denial and good works (died 1326?). She kneels on the left while Christ, showing his wounds, appears on the right with the Apostles. He gives Saint John the Evangelist a book for her inscribed 'My peace I give to you. My peace I leave you'. The chequered habit she wears is humble cloth, not the habit of any Order.
The altarpiece was probably a simple dossal, consisting of three scenes. A companion piece, 'Adoration of the Magi', is in Miami (Lowe Art Museum, Coral Gables).