The Battle of Issus (also Issos) occurred in southern Anatolia, on November 5, 333 BC between the Hellenic League led by Alexander the Great and the Achaemenid Empire, led by Darius III. It was the second great battle of Alexander's conquest of Asia, and the first encounter between Darius III and Alexander the Great. The battle resulted in the Macedonian troops defeating the Persian forces.
Albrecht Altdorfer's depiction of the moment in 333 BCE when Alexander the Great routed Darius III for supremacy in Asia Minor is vast in ambition, sweeping in scope, vivid in imagery, rich in symbols, and obviously heroic—the Iliad of painting, as literary critic Friedrich Schlegel suggested In the painting, a swarming cast of thousands of soldiers surround the central action: Alexander on his white steed, leading two rows of charging cavalrymen, dashes after a fleeing Darius, who looks anxiously over his shoulder from a chariot. The opposing armies are distinguished by the colors of their uniforms: Darius' army in red and Alexander's in blue.
1529 painting done by Albrecht Altdorfer.